Nutrients, Vol. 18, Pages 486: Association Between Regular Physical Activity and Food-Specific Inhibitory Control in Young Chinese Adults: An fMRI Study
Nutrients doi: 10.3390/nu18030486
Authors:
Yali Liu
Jialong Zou
Zihan Sun
Yuting Zhang
Xiaokai Li
Peijie Chen
Background/Objectives: Physical activity (PA) has been associated with better inhibitory control (IC), which may support self-regulatory processes related to eating. However, whether regular PA is related to food-specific IC and its neural correlates remains insufficiently understood. This cross-sectional study aimed to examine the relationship between regular PA, behavioral performance, and neural correlates of IC, with a focus on high-reward food-related contexts. Methods: Sixty-one healthy right-handed young Chinese adults were classified into a regular physical activity group (RPG; n = 30, 24 males) or an inactive group (IAG; n = 31, 17 males) based on self-reported frequency and volume of PA. Stop-signal tasks performed during functional MRI under high-calorie food and neutral image conditions were used to assess IC. Stop-signal reaction time (SSRT) indexed IC performance. Neural correlates of IC were examined using whole-brain and region-of-interest analyses, with brain activation values derived from general linear models including age, sex, body mass index, depressive scores, and subjective appetite ratings as covariates. Given the relatively small sample size and unbalanced distribution of sex and body mass index, sensitivity analyses were performed by varying covariate adjustments to assess the robustness of the primary results. Results: RPG demonstrated significantly shorter SSRT than IAG across both high-calorie food and neutral stimulus conditions. In contrast to successful-stop trials relative to baseline, IAG showed lower activation in the bilateral precuneus than RPG under the high-calorie food condition. In comparison, RPG showed lower activation than IAG under the neutral condition. In contrast to failed-stop trials relative to successful-go trials, IAG exhibited greater activation in the left caudate than RPG under the high-calorie food condition. These behavioral and neural patterns were generally robust across sensitivity analyses. Conclusions: Regular PA was associated with superior general IC, and this advantage was maintained in the presence of high-calorie food cues. At the neural level, regular PA was associated with stimulus-dependent neural responses in the bilateral precuneus and left caudate. Future studies using larger, more representative samples, objective measures of PA, and stratification by sex or BMI are warranted.
Background/Objectives: Physical activity (PA) has been associated with better inhibitory control (IC), which may support self-regulatory processes related to eating. However, whether regular PA is related to food-specific IC and its neural correlates remains insufficiently understood. This cross-sectional study aimed to examine the relationship between regular PA, behavioral performance, and neural correlates of IC, with a focus on high-reward food-related contexts. Methods: Sixty-one healthy right-handed young Chinese adults were classified into a regular physical activity group (RPG; n = 30, 24 males) or an inactive group (IAG; n = 31, 17 males) based on self-reported frequency and volume of PA. Stop-signal tasks performed during functional MRI under high-calorie food and neutral image conditions were used to assess IC. Stop-signal reaction time (SSRT) indexed IC performance. Neural correlates of IC were examined using whole-brain and region-of-interest analyses, with brain activation values derived from general linear models including age, sex, body mass index, depressive scores, and subjective appetite ratings as covariates. Given the relatively small sample size and unbalanced distribution of sex and body mass index, sensitivity analyses were performed by varying covariate adjustments to assess the robustness of the primary results. Results: RPG demonstrated significantly shorter SSRT than IAG across both high-calorie food and neutral stimulus conditions. In contrast to successful-stop trials relative to baseline, IAG showed lower activation in the bilateral precuneus than RPG under the high-calorie food condition. In comparison, RPG showed lower activation than IAG under the neutral condition. In contrast to failed-stop trials relative to successful-go trials, IAG exhibited greater activation in the left caudate than RPG under the high-calorie food condition. These behavioral and neural patterns were generally robust across sensitivity analyses. Conclusions: Regular PA was associated with superior general IC, and this advantage was maintained in the presence of high-calorie food cues. At the neural level, regular PA was associated with stimulus-dependent neural responses in the bilateral precuneus and left caudate. Future studies using larger, more representative samples, objective measures of PA, and stratification by sex or BMI are warranted. Read More