ABSTRACT
Introduction
Glucagon-like peptide-1 (GLP-1) receptor agonists represent a major therapeutic advancement, producing substantial weight loss and rapidly reshaping clinical practice, commercial markets, and policy discussions. Their accelerating adoption, however, is unfolding alongside decades of public health progress to address the complex drivers of obesity. Without integration into a broader systems-based approach, growing reliance on GLP-1 therapies risks reinforcing a reactive, treatment-driven model of obesity management that is costly, difficult to sustain, insufficient for addressing root causes, and likely perpetuating existing health inequities.
Methods
Drawing on a synthesis of existing literature and emerging clinical evidence, we apply Habits of a Systems Thinker to examine: (1) the promises and pitfalls of growing dependence on GLP-1 therapies; (2) how a systems thinking lens can illuminate unintended consequences and reveal overlooked leverage points; and (3) how dietitians and other healthcare providers can strengthen systems-based dietetic practice to promote health equity, enhance obesity care delivery, and support lasting health outcomes.
Results
We identified dominant mental models, gaps in system connections, and feedback loops that shape both obesity management and the integration of GLP-1 therapies. We also highlight potential unintended consequences and outline opportunities to adapt and act strategically within the obesity care system.
Conclusion
Dietitians hold a critical yet underutilized role, constrained by structural barriers. Fully leveraging their expertise will require system-level changes, including integrating training on a systems approach to GLP-1 therapies; strengthening connections to local and regional food resources to improve access to healthy foods; advocating for reimbursement reforms that support dietitians’ contributions to comprehensive, systems-oriented obesity care; and elevating dietitians’ roles as citizens to advance equitable obesity care.
Journal of Human Nutrition and Dietetics, Volume 39, Issue 3, June 2026. Read More