Nutrients, Vol. 17, Pages 115: A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research
Nutrients doi: 10.3390/nu17010115
Authors:
Anna Vittoria Mattioli
Francesca Coppi
Paolo Severino
Claudia Penna
Pasquale Pagliaro
Alessandra Dei Cas
Valentina Bucciarelli
Rosalinda Madonna
Cantor Tarperi
Federico Schena
Silvia Cetrullo
Tommaso Angelone
Carmine Rocca
Astrid Parenti
Alberto Palazzuoli
Alberto Margonato
Stefania Paolillo
Pasquale Perrone Filardi
Francesco Barillà
Carlo Lombardi
Marcello Pinti
Claudio Molinari
Antonio Cevese
Giuseppina Novo
Carmine Pizzi
Italo Porto
Corrado Poggesi
Sabina Gallina
Giuseppe Ambrosio
Francesco Fedele
on behalf of the Italian National Institute for Cardiovascular Research (INRC)
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management. Read More