Nutrients, Vol. 17, Pages 3401: Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy
Nutrients doi: 10.3390/nu17213401
Authors:
Jihang Xie
Sijing Su
Jianfa Wu
Xing Yang
Qian Zhang
Xiaojiang Shen
Linlin Zhao
Ting Wang
Nana Feng
Jinsong Su
Yi Zhang
Mangiferin (MF), a natural component widely found in fruits, vegetables, and herbs, has garnered increasing attention for its potent antioxidative properties and therapeutic potential. This bioactive xanthone compound plays a crucial role in mitigating oxidative stress, which is a key factor in the pathogenesis of various diseases, including liver diseases. As a powerful natural antioxidant, MF exhibits a wide range of hepatoprotective effects, making it a promising candidate for liver disease therapy. In this review, we systematically examine the source and chemical properties, synthetic pathways, pharmacokinetic characteristics, and bioavailability enhancement strategies of MF. Furthermore, we explore its mechanisms of action in treating liver diseases, with a focus on its antioxidative properties and their role in modulating liver disease progression. Given the growing burden of liver disease and the limitations of current therapies, this review aims to promote the clinical application of MF as a therapeutic candidate, paving the way for innovative therapeutic strategies for liver diseases.
Mangiferin (MF), a natural component widely found in fruits, vegetables, and herbs, has garnered increasing attention for its potent antioxidative properties and therapeutic potential. This bioactive xanthone compound plays a crucial role in mitigating oxidative stress, which is a key factor in the pathogenesis of various diseases, including liver diseases. As a powerful natural antioxidant, MF exhibits a wide range of hepatoprotective effects, making it a promising candidate for liver disease therapy. In this review, we systematically examine the source and chemical properties, synthetic pathways, pharmacokinetic characteristics, and bioavailability enhancement strategies of MF. Furthermore, we explore its mechanisms of action in treating liver diseases, with a focus on its antioxidative properties and their role in modulating liver disease progression. Given the growing burden of liver disease and the limitations of current therapies, this review aims to promote the clinical application of MF as a therapeutic candidate, paving the way for innovative therapeutic strategies for liver diseases. Read More