Nutrients, Vol. 18, Pages 112: Purified Anthocyanins Indicated No Significant Effect on Arterial Stiffness, Four-Limb Blood Pressures and Cardiovascular Risk—A 12-Week Dose–Response Trial in Chinese Middle-Aged and Elderly Adults with Hyperglycemia
Nutrients doi: 10.3390/nu18010112
Authors:
Zhaomin Liu
Minmin Li
Yuming Chen
Cheng Wang
Jianyin Chen
Huanhuan Long
Ruqing Liu
Jiachi Chiou
Chaogang Chen
Background: Diabetes is associated with sub-optimal vascular function. Current evidence suggested purified anthocyanins (ACNs) could improve cardio-metabolic health, but the dose–response effects on arterial stiffness have not been verified. Objectives: To assess the dose-responsiveness of purified ACNs on vascular stiffness and cardiovascular risk among Chinese middle-aged and elderly patients with either prediabetes or early diabetes. Methods: This was a secondary analysis based on a 12-week double-blind, randomized and placebo-controlled trial. Eligible participants were randomly assigned to placebo, 160, 320 and 640 mg/d ACNs groups (n = 46/group). Information on dietary intakes and lifestyle habits and blood samples were collected at baseline and at week 12. Arterial stiffness and vascular function were measured by brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and four-limb blood pressures. Composite cardiovascular indices were estimated based on lipids and anthropometric data. Results: Total 184 eligible participants were recruited and 19 withdrew during the intervention. Baseline characteristics were generally comparable among groups. No significant effects or dose–response relationships were observed by ACNs supplementation on arterial stiffness and cardiovascular risk factors. Conclusions: The 12-week randomized controlled trial among Chinese middle-aged and elderly adults with dysglycemia showed multiple dosages of anthocyanins had no significant impacts on arterial stiffness and cardiovascular risk.
Background: Diabetes is associated with sub-optimal vascular function. Current evidence suggested purified anthocyanins (ACNs) could improve cardio-metabolic health, but the dose–response effects on arterial stiffness have not been verified. Objectives: To assess the dose-responsiveness of purified ACNs on vascular stiffness and cardiovascular risk among Chinese middle-aged and elderly patients with either prediabetes or early diabetes. Methods: This was a secondary analysis based on a 12-week double-blind, randomized and placebo-controlled trial. Eligible participants were randomly assigned to placebo, 160, 320 and 640 mg/d ACNs groups (n = 46/group). Information on dietary intakes and lifestyle habits and blood samples were collected at baseline and at week 12. Arterial stiffness and vascular function were measured by brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and four-limb blood pressures. Composite cardiovascular indices were estimated based on lipids and anthropometric data. Results: Total 184 eligible participants were recruited and 19 withdrew during the intervention. Baseline characteristics were generally comparable among groups. No significant effects or dose–response relationships were observed by ACNs supplementation on arterial stiffness and cardiovascular risk factors. Conclusions: The 12-week randomized controlled trial among Chinese middle-aged and elderly adults with dysglycemia showed multiple dosages of anthocyanins had no significant impacts on arterial stiffness and cardiovascular risk. Read More