Nutrients, Vol. 18, Pages 799: Quercetin and Derivatives Ameliorate Metabolic Disturbances by Regulating Gut Metabolite Profiles in Mice with Circadian Rhythm Disruption and High-Fat Diet
Nutrients doi: 10.3390/nu18050799
Authors:
Hao Jiang
Yiling Xie
Xiaoqing Zheng
Jiali Lai
Xiangyun Chen
Xiantao Zheng
Hongwei Zhao
Weidong Bai
Background: Amidst evolving modern lifestyles characterized by widespread circadian rhythm disturbances and high-fat dietary habits, the incidence of metabolic disorders continues to escalate. In recent years, plant-derived bioactive compounds have attracted considerable interest as therapeutic candidates, with quercetin and its derivatives demonstrating promising potential for the regulation of metabolism. Methods: This study employed a dual-induction model of metabolic dysregulation, elicited through both circadian rhythm disruption and a high-fat diet, to systematically evaluate the regulatory effects of quercetin and its derivatives on mice through dual stimulation by circadian rhythm disruption and a high-fat diet. Results and Conclusions: Non-targeted fecal metabolomics analysis indicates that quercetin and its derivatives significantly alter the intestinal metabolite profile in mice, alleviating metabolic abnormalities induced by circadian rhythm disruption and high-fat diet. These findings provide a theoretical basis for the future development of quercetin-based functional food products.
Background: Amidst evolving modern lifestyles characterized by widespread circadian rhythm disturbances and high-fat dietary habits, the incidence of metabolic disorders continues to escalate. In recent years, plant-derived bioactive compounds have attracted considerable interest as therapeutic candidates, with quercetin and its derivatives demonstrating promising potential for the regulation of metabolism. Methods: This study employed a dual-induction model of metabolic dysregulation, elicited through both circadian rhythm disruption and a high-fat diet, to systematically evaluate the regulatory effects of quercetin and its derivatives on mice through dual stimulation by circadian rhythm disruption and a high-fat diet. Results and Conclusions: Non-targeted fecal metabolomics analysis indicates that quercetin and its derivatives significantly alter the intestinal metabolite profile in mice, alleviating metabolic abnormalities induced by circadian rhythm disruption and high-fat diet. These findings provide a theoretical basis for the future development of quercetin-based functional food products. Read More